Trachette Jackson, University of Michigan
March 13, 2007
Abstract: It is now appreciated that cancers can be composed of multiple clonal subpopulations of cancer cells which differ among themselves in many properties, including, growth rate, ability to metastasize, immunological characteristics, production and expression of markers, and sensitivity to therapeutic modalities. Such tumor heterogeneity has been demonstrated in a wide variety of tumors, including those that originate in the prostate. In an effort to assist in the understanding of recurrent prostate cancer and the cellular processes which mediate this disease, I will present a mathematical model that describes both the pre-treatment growth and the post-therapy relapse of human prostate cancer xenografts. The goal is to evaluate the interplay between the multiple mechanisms which have been postulated as causes of androgen-independent relapse. At the end of the the talk, I will also comment on possible causes of tumor heterogeneity including the Cancer Stem Cell Hypothesis.
Biography: Trachette Jackson is an associate professor at the University of Michigan. She received a Ph.D. in Applied Mathematics in 1998 from the University of Washington. Her research interests focus on applying mathematics to modeling the growth and control of cancer. Professor Jackson has held post doctoral positions at Duke University, the Institute of Mathematics and its Applications at the University of Minnesota, and the National Health and Environmental Effects Research Laboratory of the Environmental Protection Agency. She is the recipient of an Alfred P. Sloan Research Fellowship and the Career Enhancement Fellowship from the Woodrow Wilson National Foundation. At the University of Michigan she received the Amoco Faculty Undergraduate Teaching Award. She is currently a Co-PI on an NSF grant for a program that will allow undergraduate students to develop knowledge and acquire skills in research areas that are at the interface of Biology and Mathematics. Professor Jackson is a frequent invited lecturer at conferences and universities.