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Targeted Cancer Treatment in Silico

Natalia L. Komarova and Dominik Wodarz
Publisher: 
Birkhäuser
Publication Date: 
2013
Number of Pages: 
227
Format: 
Hardcover
Series: 
Modeling and Simulation in Science, Engineering and Technology
Price: 
69.99
ISBN: 
9781461483007
Category: 
Monograph
We do not plan to review this book.

Background and Scope of the Book.- Part I Treatment of Cancer with Small Molecule Inhibitors.- An Introduction to Small Molecule Inhibitors and Chronic Myeloid Leukemia.- Basic Dynamics of Chronic Myeloid Leukemia During Imatinib Treatment.- Stochastic Modeling of Cellular Growth, Treatment, and Resistance Generation.- Evolutionary Dynamics of Drug Resistant Mutants in Targeted Treatment of CML.- Effect of Cellular Quiescence on the Evolution of Drug Resistance in CML.- Combination Therapies: Short term versus Long term Strategies.- Cross Resistance: Treatment and Modeling.- Mathematical Modeling of Cyclic Cancer Treatments.- Part II Treatment of Cancer with Oncolytic Viruses.- Introduction to Oncolytic Viruses.- Basic Dynamics of Oncolytic Viruses.- Mitotic Virus Transmission and Immune Responses.- Axiomatic Approaches to Oncolytic Virus Modeling.- Spatial Oncolytic Virus Dynamics.- Oncolytic Viruses and the Eradication of Drug-resistant Tumor Cells.

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